Hydrochloric Acid → HCID 178527757, 화합물
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([NH2:8])[CH:7]=1.CCO[C:13]([S-:15])=[S:14].[K+].Cl>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[S:14][C:13]([SH:15])=[N:8][C:6]=2[CH:7]=1참가 물질
5
반응 조건
- 온도
- 140 °C
실험 절차
To a solution of 5-bromo-2-fluorobenzenamine (200 mg, 1.28 mmol) in N-methyl-2-pyrrolidine (1.5 mL) was added potassium o-ethyl carbonodithioate (410 mg, 2.56 mmol). The mixture was heated at 140° C. for 2 h. The reaction mixture was poured into a large amount of water, acidified with concentrated hydrochloric acid, and filtered to give 5-bromo-benzothiazole-2-thiol 300 mg (95%).
후처리
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-8e3a3c27c01342b0a1b6fadb229feeb9
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08772285B2
반응 노트
불러오는 중…