Hydrochloric Acid → (R)-Quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride

HRID 1619508

반응식

HRID 1619508 반응식
C(OC([NH:8][CH:9]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]([O:12][C@@H:13]1[CH:18]2[CH2:19][CH2:20][N:15]([CH2:16][CH2:17]2)[CH2:14]1)=[O:11])=O)(C)(C)C.[ClH:27]>C1COCC1>[ClH:27].[ClH:27].[NH2:8][CH:9]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]([O:12][C@@H:13]1[CH:18]2[CH2:17][CH2:16][N:15]([CH2:20][CH2:19]2)[CH2:14]1)=[O:11]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67425060(R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-phenylacetate

생성물 1

HCID 67425463(R)-Quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride수율 100.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-phenylacetate (C1) (1.25 g, 3.47 mmol) in THF (20 ml), was added 37% hydrogen chloride (2.00 ml, 24.3 mmol) dropwise. The reaction was stirred at RT for 15 hours. The solvent was evaporated to obtain (R)-quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride (1.16 g; quantitative yield) as a solid. The compound was used in the next step without any further purification.

후처리

  1. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-2cbc7e4218c54fd884a503568f50ac5f
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772314B2

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