Hydrochloric Acid → 2-hydroxy-N-(5-(methylsulfinyl)thiazol-2-yl)benzamide

HRID 1620892

반응식

HRID 1620892 반응식
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:21])[NH:12][C:13]1[S:14][C:15]([S:18]([CH3:20])=[O:19])=[CH:16][N:17]=1)(=O)C.Cl>C1COCC1>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([NH:12][C:13]1[S:14][C:15]([S:18]([CH3:20])=[O:19])=[CH:16][N:17]=1)=[O:21]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 569693972-(5-(Methylsulfinyl)thiazol-2-ylcarbamoyl)phenyl acetate

생성물 1

HCID 569696152-hydroxy-N-(5-(methylsulfinyl)thiazol-2-yl)benzamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 11 (1.0 g, 3.1 mmol) is dissolved in THF (20 mL) and is added under stirring to 2M HCl (100 mL). The reaction is refluxed for one hour and is allowed to cool under stirring over one hour. The product is filtered using a sintered glass funnel, washed with distilled water and THF and dried in high vacuum and affords 12 as a colorless solid.

후처리

  1. additionis added
  2. temperatureThe reaction is refluxed for one hour
  3. temperatureto cool
  4. filtrationThe product is filtered
  5. washwashed with distilled water and THF
  6. customdried in high vacuum

출처 및 근거

ORD 기록
ord-7aab2f2e0d7e4a35b9fb58228235f10f
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772502B2

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