Ethanol → HCID 67288578, 화합물

HRID 1626478노트

반응식

HRID 1626478 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:31])[NH:20][CH2:21][CH2:22][C:23]3[C:28]([Cl:29])=[CH:27][C:26]([Cl:30])=[CH:25][N:24]=3)=[CH:15][CH:14]=1)[O:8][CH2:7][CH2:6][CH:5]2[C:32]([O:34]CC)=[O:33].[OH-].[Na+].[CH2:39](O)[CH3:40]>C1COCC1.C(OCC)(=O)C.Cl>[CH2:39]([CH:7]1[CH2:6][CH:5]([C:32]([OH:34])=[O:33])[C:4]2[C:9](=[CH:10][C:11]([O:12][C:13]3[CH:18]=[CH:17][C:16]([C:19](=[O:31])[NH:20][CH2:21][CH2:22][C:23]4[C:28]([Cl:29])=[CH:27][C:26]([Cl:30])=[CH:25][N:24]=4)=[CH:15][CH:14]=3)=[C:2]([Cl:1])[CH:3]=2)[O:8]1)[CH3:40]

참가 물질

7

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 67288212HCID 67288212, 화합물

생성물 1

HCID 67288578HCID 67288578, 화합물수율 100%

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

Ethyl 6-chloro-7-(4-(2-(3,5-dichloropyridin-2-yl)ethylcarbamoyl)phenoxy)chroman-4-carboxylate (40 mg, 0.073 mmol) was diluted with THF (500 μl) followed by the addition of NaOH (364 μl, 0.36 mmol) and ethanol (300 μl). After stirring for 3 hours, the reaction was diluted with ethyl acetate and 2N HCl. The layers were separated and the organic layer was dried over MgSO4, filtered and concentrated to yield the desired compound (38 mg, 0.073 mmol, 100% yield).

후처리

  1. customThe layers were separated
  2. dry with materialthe organic layer was dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e6710fa5722e4f58a97478b98e4c6ec6
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785445B2

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