Water → FA amoxicillin

HRID 1629636

반응식

HRID 1629636 반응식
[CH3:1][C:2]1([CH3:25])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:21])[C:14]3[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:22]([OH:24])=[O:23].O.C(N=C=NCCCN(C)C)C.[CH:38]1[C:43]([NH2:44])=[CH:42][C:41]2[C:45]([O:47][C:48]3([C:58]4[CH:59]=[CH:60][C:61]([OH:63])=[CH:62][C:57]=4[O:56][C:50]4[CH:51]=[C:52]([OH:55])[CH:53]=[CH:54][C:49]3=4)[C:40]=2[CH:39]=1)=[O:46]>C(#N)C>[CH:38]1[C:43]([NH2:44])=[CH:42][C:41]2[C:45]([O:47][C:48]3([C:58]4[CH:59]=[CH:60][C:61]([OH:63])=[CH:62][C:57]=4[O:56][C:50]4[CH:51]=[C:52]([OH:55])[CH:53]=[CH:54][C:49]3=4)[C:40]=2[CH:39]=1)=[O:46].[CH3:1][C:2]1([CH3:25])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:21])[C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:22]([OH:24])=[O:23]

참가 물질

6

반응물 4

HCID 962WaterHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 33613Amoxicillin2회HCID 768455-Aminofluorescein4회

생성물 1

HCID 131731698FA amoxicillin

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Fluoresceinamine (FA; 0.0583 g) was dissolved in 1.0 ml acetonitrile to from a FA solution. Amoxicillin (0.1 g) was dissolved in 30 ml deionized water, and mixed with the aforesaid FA solution. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (0.0408 g) was added thereto and magnetically stirred at room temperature in the dark for 12 hours to make FA to graft to the carboxyl group of amoxicillin to form a fluorescent-labeled FA-amoxicillin. And, finally, the sample was freeze-dried to collect the fluorescent-labeled FA-amoxicillin.

출처 및 근거

ORD 기록
ord-adb1b15315a040e0ac32635795454c18
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08790695B2

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