Cesium carbonate → 1-{2-Chloro-5-[(R)-1-(4-chloro-3,5-dimethyl-phenyl)-propylamino]-benzyl}-azetidine-3-carboxylic acid tert-butyl ester

반응식

[C:1]([O:5][C:6]([CH:8]1[CH2:11][N:10]([CH2:12][C:13]2[CH:18]=[C:17](Br)[CH:16]=[CH:15][C:14]=2[Cl:20])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:21][C:22]1[C:27]([CH3:28])=[CH:26][C:25]([C@H:29]([NH2:32])[CH2:30][CH3:31])=[CH:24][C:23]=1[CH3:33].C(=O)([O-])[O-].[Cs+].[Cs+].CC(C1C=C(C(C)C)C(C2C=CC=CC=2P(C2CCCCC2)C2CCCCC2)=C(C(C)C)C=1)C>C1(C)C=CC=CC=1.C(O)(C)(C)C.CCOC(C)=O.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[C:1]([O:5][C:6]([CH:8]1[CH2:11][N:10]([CH2:12][C:13]2[CH:18]=[C:17]([NH:32][C@@H:29]([C:25]3[CH:24]=[C:23]([CH3:33])[C:22]([Cl:21])=[C:27]([CH3:28])[CH:26]=3)[CH2:30][CH3:31])[CH:16]=[CH:15][C:14]=2[Cl:20])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]