Hydrochloric Acid → HCID 66847784, 화합물

HRID 1631345노트

반응식

HRID 1631345 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@@H:9]1[N:13]([C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23]([O:25]CC)=[O:24])=[C:16]3[N:15]=2)[C:12]([CH3:29])([CH3:28])[CH2:11][CH2:10]1.[OH-].[Na+].Cl>CO.[Cl-].[Na+].O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@@H:9]1[N:13]([C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23]([OH:25])=[O:24])=[C:16]3[N:15]=2)[C:12]([CH3:29])([CH3:28])[CH2:11][CH2:10]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86664571HCID 86664571, 화합물

생성물 1

HCID 66847784HCID 66847784, 화합물수율 97.2%

시약·촉매·용매 2

HCID 887Methanol용매HCID 57417360Sodium chloride; water용매

실험 절차

(R)-ethyl 5-(5-(2,5-difluorophenyl)-2,2-dimethylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate (136 mg, 0.340 mmol) was dissolved in MeOH (5.0 mL) and 1N NaOH (3.40 mL, 3.40 mmol) was added. The reaction was stirred at ambient temperature for 5 days and then heated at reflux for 4 hours. The reaction mixture was cooled, poured onto a mixture of brine (10 mL) and 2N HCl (5 mL) and extracted with DCM. The combined organic extracts were filtered through PS paper and concentrated to provide the title compound (123 mg, 97% yield) as a beige solid. MS (apci) m/z=373.0 (M+H).

후처리

  1. temperatureheated
  2. temperatureat reflux for 4 hours
  3. temperatureThe reaction mixture was cooled
  4. extractionextracted with DCM
  5. filtrationThe combined organic extracts were filtered through PS paper
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-350bd349b06542788116675342a75e2d
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791123B2

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