Sodium Hydroxide → 4-(5-Fluoro-2-methoxyphenyl)piperidine

HRID 1633576노트

반응식

HRID 1633576 반응식
C([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[O:16][CH3:17])[CH2:5][CH2:4]1)=O.[OH-].[Na+]>Cl.CO>[F:15][C:13]1[CH:12]=[CH:11][C:10]([O:16][CH3:17])=[C:9]([CH:6]2[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]2)[CH:14]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 15512821HCID 15512821, 화합물

생성물 1

HCID 155128224-(5-Fluoro-2-methoxyphenyl)piperidine

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

실험 절차

The crude product of 1-formyl-4-(5-fluoro-2-methoxy-phenyl)-piperidine (0.80 g, 3.4 mmole) was dissolved in HCl (16 mL, 0.5 N) and MeOH (5 mL), and the mixture was brought to reflux for 16 hours. The mixture was cooled to room temperature and basified with NaOH (2.5 N), and extracted with EtOAc (3×25 mL) to give 4-(5-fluoro-2-methoxy-phenyl)-piperidine which was used directly without further purification.

후처리

  1. temperatureto reflux for 16 hours
  2. extractionextracted with EtOAc (3×25 mL)

출처 및 근거

ORD 기록
ord-179f056309ed4aac9714856b40099491
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06503928B2

반응 노트

불러오는 중…