Iodoethane → HCID 18675866, 화합물

HRID 1635090노트

반응식

HRID 1635090 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][C:9]#[N:10])[C:3]=1[O:11][CH3:12].[H-].[Na+].[CH2:15](I)[CH3:16]>C1COCC1.O>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]([CH2:15][CH3:16])[C:9]#[N:10])[C:3]=1[O:11][CH3:12]

참가 물질

6

반응물 3

HCID 6340IodoethaneHCID 24758Sodium hydrideHCID 186758634-Chloro-3-methoxy-2-pyridineacetonitrile

생성물 1

HCID 18675866HCID 18675866, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
45 °C

실험 절차

2-(4-Chloro-3-methoxy-2-pyridinyl)-acetonitrile (7.06 g) is dissolved in THF (40 ml) and 60% sodium hydride (1.62 g) is added followed by 3.25 ml of ethyl iodide. The reaction is allowed to stir at 45° C. for 1.5 hour then the reaction mixture is diluted with water and extracted with ethyl acetate. The desired product is purified by chromatography using hexane/ethyl acetate 4/1 as solvent.

후처리

  1. extractionextracted with ethyl acetate
  2. customThe desired product is purified by chromatography

출처 및 근거

ORD 기록
ord-682b59012d7f49cba69278c1797345c1
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06509349B1

반응 노트

불러오는 중…