Dimethoxymethane → 4-(Ethylthio)benzyl chloride

HRID 1635964

반응식

HRID 1635964 반응식
[Cl-:1].[Al+3].[Cl-].[Cl-].[CH3:5]OCOC.[CH2:10]([S:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH3:11]>ClCCCl>[CH2:10]([S:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:5][Cl:1])=[CH:15][CH:14]=1)[CH3:11]

참가 물질

5

반응물 3

HCID 8020DimethoxymethaneHCID 12144(Ethylthio)benzeneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 186738584-(Ethylthio)benzyl chloride

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

반응 조건

온도
5 °C

실험 절차

Aluminum chloride (2 g, 15 mmol) was suspended in 8 mL 1,2-dichloroethane and the solution was cooled to 5° C. Dimethoxymethane (0.69 mL, 7.8 mmol) over 10 min. Ethylphenylsulfide (0.88 mL, 6.5 mmol) was added and the mixture was warmed to rt. After 15 h ice water was added and the mixture was extracted with methylene chloride (3×). The combined organic fractions were dried over magnesium sulfate and concentrated. The crude material was used directly in the next step.

후처리

  1. temperaturethe mixture was warmed to rt
  2. extractionthe mixture was extracted with methylene chloride (3×)
  3. dry with materialThe combined organic fractions were dried over magnesium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-28964c644ded4d8ebef150e94210722b
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06511994B2

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