Iodine chloride → 2-(4'-Amino-3'-iodophenyl)-6-methoxybenzothiazole

HRID 1636554

반응식

HRID 1636554 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[I:19]Cl>C(O)(=O)C>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][C:7]=1[I:19]

참가 물질

4

반응물 2

HCID 24640Iodine chlorideHCID 3918704-(6-Methoxy-1,3-benzothiazol-2-yl)aniline

생성물 1

HCID 100684372-(4'-Amino-3'-iodophenyl)-6-methoxybenzothiazole수율 56.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2-(4'-Aminophenyl)-6-methoxybenzothiazole (0.22 g, 0.84 mmol) was treated with iodine monochloride (0.21 g, 1.3 mmol) in acetic acid according to the above-described general procedure for iodination. Crude product was purified by flash chromatography on silica gel, using ethyl acetate-hexane (1:3) as eluent, to give brown small crystals (0.18 g, 54.9%), m.p. 179.2-181.1° C.

후처리

  1. customCrude product was purified by flash chromatography on silica gel

출처 및 근거

ORD 기록
ord-06fc31bab1024d1a891d176b03be7e52
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06034246

연결된 노트

불러오는 중…