Iodine chloride → 2-(4'-Amino-3'-iodophenyl)benzoxazole

HRID 1636555

반응식

HRID 1636555 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[I:17]Cl>C(O)(=O)C>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][C:7]=1[I:17]

참가 물질

4

반응물 2

HCID 24640Iodine chlorideHCID 88733Benzenamine, 4-(2-benzoxazolyl)-

생성물 1

HCID 106645602-(4'-Amino-3'-iodophenyl)benzoxazole수율 65.8%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2-(4'-Aminophenyl)benzoxazole (0.14 g, 1.9 mmol) was treated with iodine monochloride (0.37 g, 2.23 mmol) in acetic acid according to the above-described general procedure for iodination. Crude product was purified by flash chromatography on silica gel using ethyl acetate-hexane (1:2) as eluent to give a brown powder (0.42 g, 65.7%), m.p. 188.0-191.2° C.

후처리

  1. customCrude product was purified by flash chromatography on silica gel

출처 및 근거

ORD 기록
ord-a07fadc62b394afeb50f1cdbfe96ed79
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06034246

연결된 노트

불러오는 중…