Trityl chloride → Ethyl 1-trityl-1H-imidazole-4-carboxylate

HRID 1636813노트

반응식

HRID 1636813 반응식
[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:3]=[CH:2]1.C(N(CC)CC)C.[C:18](Cl)([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(Cl)(Cl)Cl>[C:18]([N:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:3]=[CH:2]1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

참가 물질

5

반응물 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 178469898HCID 178469898, 화합물

생성물 1

HCID 618225Ethyl 1-trityl-1H-imidazole-4-carboxylate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A suspension of ethyl imidazole-4-carboxylate (1.4 g), triethylamine (1.2 g) and chloroform (20 ml) was stirred at room temperature while trityl chloride (3.06 g) was added, and the mixture was stirred at room temperature for 1 h. The resulting solution was washed with water, dried and evaporated to dryness under reduced pressure, and the residue was crystallised from a mixture of ethyl acetate and cyclohexane, to give ethyl 1-tritylimidazole-4-carboxylate, mp 163°-164°.

후처리

  1. additionwas added
  2. washThe resulting solution was washed with water
  3. customdried
  4. customevaporated to dryness under reduced pressure
  5. customthe residue was crystallised from a mixture of ethyl acetate and cyclohexane

출처 및 근거

ORD 기록
ord-91ce51a165e840c2a0015a804d1ff624
출처 데이터셋
uspto-grants-2000_03
특허 번호
USRE036617

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