Hydrogen Peroxide → 2-Butyl-5-formylimidazole

HRID 1637367

반응식

HRID 1637367 반응식
[CH2:1]([C:5]1[NH:6][C:7]([CH2:10][OH:11])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].[Bi].[OH-].[Na+].OO>[Pt].O>[CH2:1]([C:5]1[NH:6][C:7]([CH:10]=[O:11])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

7

반응물 4

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 27356732-Butyl-5-hydroxymethylimidazoleHCID 5359367Bismuth

생성물 1

HCID 27356712-Butyl-5-formylimidazole수율 100%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 962Water용매

실험 절차

2.0 g of 2-n-butyl-5-hydroxymethylimidazole, 0.3 g of 5 percent platinum and 5 percent bismuth on activated carbon (comprising 61.3 percent water), 13 ml of 1 N NaOH solution and 7 g of H2O were heated to about 60° C. with stirring. At 60° to 64° C., 3.4 g of 15 percent strength aqueous H2O2 solution was added dropwise over the course of 45 min. The reaction mixture was then allowed to react for 15 min and then filtered. The pH of the filtrate was adjusted from 13.4 to 9.0 using 20 percent H2SO4, as a result of which a pale yellow suspension formed. This was cooled, and the crude product was able to be filtered off and/or extracted with methylene chloride. The reaction was monitored by GC analysis. The reaction yield was 100 percent (0 percent of starting material).

후처리

  1. customto react for 15 min
  2. filtrationfiltered
  3. customas a result of which a pale yellow suspension
  4. customformed
  5. temperatureThis was cooled
  6. filtrationto be filtered off
  7. extractionextracted with methylene chloride
  8. customThe reaction yield was 100 percent (0 percent of starting material)

출처 및 근거

ORD 기록
ord-182584dcf00c4aa2a264f236ea90d098
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06040457

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