Hydrochloric Acid → HCID 178516554, 화합물

HRID 1638481

반응식

HRID 1638481 반응식
C[C:2](C)([O-:4])C.[K+].[C:7]1([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15][C:14]2=[O:22])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(OCC)=O.Cl>O.C(O)C>[C:7]1([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15](=[CH:2][OH:4])[C:14]2=[O:22])[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 3147871-PhenyloxindoleHCID 23665647Potassium tert-butoxide

생성물 1

HCID 178516554HCID 178516554, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Potassium t-butoxide (1.63 g, 14.5 mmoles) and 5 ml absolute ethanol were heated to 80°. 1-Phenyl-2(1H, 3H)-indolone 2.09 g, 10 mmoles) was added, followed by ethyl formate (1.09 ml, 13.5 mmoles). The mixture was heated 5 minutes, cooled to 25°, and the nearly solid mass diluted with 50 ml H2O and crushed ice, acidified to pH 3 with 3N HCl and title product recovered by filtration, 2.2 g, m.p. 192°-195°; m/e 237. cf J. Prakt. Chem. 135:345-360 (1932); J. Med. Chem. 8:637 (1965).

후처리

  1. temperatureThe mixture was heated 5 minutes
  2. temperaturecooled to 25°
  3. customcrushed ice

출처 및 근거

ORD 기록
ord-9fff835d51e94d4095668ce0deae765b
출처 데이터셋
uspto-grants-1989_11
특허 번호
US04879391

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