Sodium Hydroxide → trans-2-(2-methyl-2H-indazol-4-yl)cyclopropanecarbaldehyde oxime

HRID 1639755노트

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HRID 1639755 반응식
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[C:8]2[C@@H:11]2[CH2:13][C@H:12]2[CH:14]=O)=[N:3]1.[OH-:16].[Na+].Cl.[NH2:19]O>C(O)C.O>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[C:8]2[C@@H:11]2[CH2:13][C@H:12]2[CH:14]=[N:19][OH:16])=[N:3]1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 86641920trans-2-(2-methyl-2H-indazol-4-yl)cyclopropanecarbaldehyde

생성물 1

HCID 86641922trans-2-(2-methyl-2H-indazol-4-yl)cyclopropanecarbaldehyde oxime수율 98.3%

시약·촉매·용매 1

HCID 19096565Water ethanol용매

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온도
60 °C

실험 절차

Trans-2-(2-methyl-2H-indazol-4-yl)cyclopropanecarbaldehyde (330 mg, 1.65 mmol), 8 M aqueous sodium hydroxide solution (824 μL, 6.59 mmol) and hydroxylamine hydrochloride (378 mg, 5.44 mmol) were dissolved in ethanol/water (15 mL/3 mL), and the mixture was stirred at 60° C. for 3 hr. The reaction solution was concentrated, extracted with ethyl acetate, washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (349 mg, yield 98%).

후처리

  1. concentrationThe reaction solution was concentrated
  2. extractionextracted with ethyl acetate
  3. washwashed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-967d83feb3834e60b42f321216201b05
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110585B2

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