Sodium Hydroxide → trans-2-(2-Methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropanecarbaldehyde oxime

HRID 1639756노트

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HRID 1639756 반응식
[CH3:1][C:2]1[CH:15]=[C:5]2[C:6]([C@@H:10]3[CH2:12][C@H:11]3[CH:13]=O)=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1.[OH-:16].[Na+].Cl.[NH2:19]O>C(O)C.O>[CH3:1][C:2]1[CH:15]=[C:5]2[C:6]([C@@H:10]3[CH2:12][C@H:11]3[CH:13]=[N:19][OH:16])=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 86641921trans-2-(2-Methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropanecarbaldehyde

생성물 1

HCID 86641923trans-2-(2-Methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropanecarbaldehyde oxime수율 96%

시약·촉매·용매 1

HCID 19096565Water ethanol용매

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온도
60 °C

실험 절차

Trans-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropanecarbaldehyde (1.62 g, 8.08 mmol), 8 M aqueous sodium hydroxide solution (4.04 mL, 32.3 mmol) and hydroxylamine hydrochloride (1.85 g, 26.7 mmol) was dissolved in ethanol/water (65 mL/13 mL), and the mixture was stirred at 60° C. for 3 hr. The reaction solution was concentrated, extracted with ethyl acetate, washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (1.67 g, yield 96%).

후처리

  1. concentrationThe reaction solution was concentrated
  2. extractionextracted with ethyl acetate
  3. washwashed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-bcb257a54ee1455985a63694bb43bc39
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110585B2

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