Sodium Hydroxide → 2,3-dihydro-1H-indol-5-ol

HRID 1640256노트

반응식

HRID 1640256 반응식
C([BH3-])#N.[Na+].[OH:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]=[CH:9]2.[OH-].[Na+]>C(O)(=O)C>[NH:11]1[C:12]2[C:8](=[CH:7][C:6]([OH:5])=[CH:14][CH:13]=2)[CH2:9][CH2:10]1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 160545-HydroxyindoleHCID 5003444Sodium cyanoborohydride

생성물 1

HCID 100346842,3-dihydro-1H-indol-5-ol

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Under a nitrogen atmosphere 0.34 g sodium cyanoborohydride were added batchwise to 0.60 g (4.5 mmol) 5-hydroxyindole in 5.0 mL glacial acetic acid and the mixture was stirred for 60 min at RT. Then the reaction mixture was poured onto a 4N aqueous sodium hydroxide solution and extracted with EtOAc. The combined organic phases were washed several times with saturated sodium hydrogen carbonate solution, dried on sodium sulphate and evaporated down.

후처리

  1. extractionextracted with EtOAc
  2. washThe combined organic phases were washed several times with saturated sodium hydrogen carbonate solution
  3. customdried on sodium sulphate
  4. customevaporated down

출처 및 근거

ORD 기록
ord-7fb701233e8b4271a07233300e72cd16
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110575B2

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