Hydrochloric Acid → 5-(6-(2-propylindoline-1-carbonyl)pyrimidin-4-ylamino)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

HRID 1640269

반응식

HRID 1640269 반응식
Cl.Cl[C:3]1[N:8]=[CH:7][N:6]=[C:5]([C:9]([N:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH:12]2[CH2:20][CH2:21][CH3:22])=[O:10])[CH:4]=1.[NH2:23][C:24]1[CH:25]=[C:26]2[C:39](=[CH:40][CH:41]=1)[CH2:38][C:28]1([C:36]3[C:31](=[N:32][CH:33]=[CH:34][CH:35]=3)[NH:30][C:29]1=[O:37])[CH2:27]2>CC(O)CCC>[CH2:20]([CH:12]1[CH2:13][C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:11]1[C:9]([C:5]1[N:6]=[CH:7][N:8]=[C:3]([NH:23][C:24]2[CH:25]=[C:26]3[C:39](=[CH:40][CH:41]=2)[CH2:38][C:28]2([C:36]4[C:31](=[N:32][CH:33]=[CH:34][CH:35]=4)[NH:30][C:29]2=[O:37])[CH2:27]3)[CH:4]=1)=[O:10])[CH2:21][CH3:22]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 58117516(6-Chloro-pyrimidin-4-yl)-(2-propyl-2,3-dihydro-indol-1-yl)-methanoneHCID 591667225-amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

생성물 1

HCID 498036525-(6-(2-propylindoline-1-carbonyl)pyrimidin-4-ylamino)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

시약·촉매·용매 1

HCID 223862-Pentanol용매

실험 절차

12.5 μL (50 μmol) 4M aqueous hydrochloric acid were added to 103 mg (0.40 mmol) (6-chloro-pyrimidin-4-yl)-(2-propyl-2,3-dihydro-indol-1-yl)-methanone and 108 mg (0.36 mmol) 5-amino-1,3-dihydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one in 2 mL 2-pentanol. The reaction mixture was refluxed for 2 h. The reaction mixture was evaporated down using the rotary evaporator and the residue was taken up in DMF. The purification was carried out by preparative HPLC. The product fractions were combined and lyophilised.

후처리

  1. temperatureThe reaction mixture was refluxed for 2 h
  2. customThe reaction mixture was evaporated down
  3. customthe rotary evaporator
  4. customThe purification

출처 및 근거

ORD 기록
ord-5aefc3e395b44e2a942b661480a8732f
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110575B2

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