4-(2-Fluoro-4-nitrophenoxy)-1-benzofuran → 4-(1-Benzofuran-4-yloxy)-3-fluorophenylamine

HRID 16410

반응식

HRID 16410 반응식
[F:1][C:2]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:3]=1[O:4][C:5]1[C:10]2[CH:11]=[CH:12][O:13][C:9]=2[CH:8]=[CH:7][CH:6]=1>C(O)C.O1CCCC1.[Pt](=O)=O>[O:13]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([O:4][C:3]3[CH:14]=[CH:15][C:16]([NH2:18])=[CH:17][C:2]=3[F:1])[C:10]=2[CH:11]=[CH:12]1

참가 물질

4

반응물 1

HCID 179793424-(2-Fluoro-4-nitrophenoxy)-1-benzofuran

생성물 1

HCID 179793044-(1-Benzofuran-4-yloxy)-3-fluorophenylamine

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 21873804Tetrahydrofuran ethanol용매

실험 절차

Under argon, 150 mg (0.55 mmol) of 4-(2-fluoro-4-nitrophenoxy)-1-benzofuran (from example XXII) are initially charged in 5 ml of ethanol/tetrahydrofuran (1:1), platinum(IV) oxide is added and the mixture is hydrogenated under atmospheric pressure for 2 hours. The suspension is filtered off through CELITE (diatomaceous earth), the filtercake is washed with ethanol and the filtrate is concentrated using a rotary evaporator.

후처리

  1. filtrationThe suspension is filtered off through CELITE (diatomaceous earth)
  2. washthe filtercake is washed with ethanol
  3. concentrationthe filtrate is concentrated
  4. customa rotary evaporator

출처 및 근거

ORD 기록
ord-e3cf80b818b84914a527d46ea5c07013
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737153B2

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