2-Methylindanone → Methylindan-1-one oxime

HRID 1641377

반응식

HRID 1641377 반응식
[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=O.Cl.[NH2:13][OH:14].C([O-])(=O)C.[Na+]>C(O)C.O>[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[N:13][OH:14]

참가 물질

6

반응물 3

HCID 2492622-MethylindanoneHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 73454082Methylindan-1-one oxime수율 89.8%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

A mixture of 2-methyl-1-indanone (10 g, 0.0684 mol) and hydroxylamine hydrochloride (9.5 g, 0.1368 mol) in ethanol was stirred at 60° C., and a solution of sodium acetate (16.8 g, 0.2052 mol) in water added. The resulting mixture was then heated at reflux for 90 minutes, then cooled and the solid filtered. The crude product was washed with water and filtered to give 2-methyl-indan-1-one oxime (9.9 g, yield 81%), mp. 82-91° C., in 90% purity.

후처리

  1. temperatureThe resulting mixture was then heated
  2. temperatureat reflux for 90 minutes
  3. temperaturecooled
  4. filtrationthe solid filtered
  5. washThe crude product was washed with water
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-bc3dafd1fd074be09964f9c4bf057cae
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08114991B2

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