Hydrochloric Acid → 4-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile

HRID 16425

반응식

HRID 16425 반응식
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[NH2:10][C:11]1[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=1.Cl>O>[NH2:1][C:2]1[N:3]=[C:4]([NH:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=2)[CH:5]=[C:6]([Cl:8])[N:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 133964-AminobenzonitrileHCID 655222-Amino-4,6-dichloropyrimidine

생성물 1

HCID 2408064-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

300 mg (1.83 mmol) of 2-amino-4,6-dichloropyrimidine and 216 mg (1.83 mmol) of 4-aminobenzonitrile are suspended in 6 ml of water. 180 μl of concentrated hydrochloric acid are added, and the mixture is stirred at 100° C. overnight. The precipitate is filtered off with suction.

후처리

  1. filtrationThe precipitate is filtered off with suction

출처 및 근거

ORD 기록
ord-b294971d5690468ca48fed2a90495ae2
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737153B2

연결된 노트

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