1-Benzyl-4-(pyridin-3-YL)piperidin-4-OL → 4-(Pyridin-3-yl)piperidin-4-ol

HRID 1643433

반응식

HRID 1643433 반응식
C([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>[Pd].CO.C(Cl)(Cl)Cl>[N:17]1[CH:18]=[CH:19][CH:20]=[C:15]([C:11]2([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:16]=1

참가 물질

6

반응물 2

HCID 10940791-Benzyl-4-(pyridin-3-YL)piperidin-4-OLHCID 2723923Ammonium formate

생성물 1

HCID 49891674-(Pyridin-3-yl)piperidin-4-ol

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매2회HCID 6212Chloroform용매

반응 조건

온도
68 °C

실험 절차

(Apparatus: 1 I three-necked flask with condenser) Palladium on charcoal (10%, catalytic amount) was added to a solution of 1-benzyl-4-(pyridin-3-yl)piperidin-4-ol (32 g) in methanol (220 ml), followed by ammonium formate solution (22.7 g in 50 ml of water). The reaction mixture was refluxed at 68° C. overnight. Thin layer chromatography control: 20% methanol in chloroform. The mixture was filtered over Celite and the filtrate was concentrated in vacuo. The residue was washed with acetone (100 ml) in order to obtain the desired compound in a pure form. Yield: 17.3 g (81%)

후처리

  1. filtrationThe mixture was filtered over Celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. washThe residue was washed with acetone (100 ml) in order

출처 및 근거

ORD 기록
ord-e09f3ab50bd2422d8bb92ccb82c28e45
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119805B2

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