Hydrochloric Acid → 1-Naphthalenecarboxaldehyde, 5,6,7,8-tetrahydro-4-hydroxy-

5, 6,7,8-Tetrahydro-naphthalen-1-ol (108, 20 g, 135 mmol) was stirred in 100 mL of ethanol, and potassium hydroxide (7.57 g, 135 mmol) as an aqueous solution was added. The mixture was stirred for 15 minutes and went clear. Solvents were removed and dried. PEG (MW 380-420, 53 mL) was added, followed by chloroform (32.3 mL, 405 mmol) and toluene (34 mL). An aqueous potassium hydroxide solution (50% by weight, 54.4 mL) was introduced dropwise with stirring over 15 minutes. The stirring was continued for another 30 minutes. 1M HCl was added to acidify the reaction mixture and it was extracted with EtOAc three times. The combined organic layers were washed with water and brine The combined organic layers were dried over MgSO4, filtered, concentrated, and purified by flash chromatography (0-40% EtOAc/hexane) to give 4-hydroxy-5,6,7, 8-tetrahydro-naphthalene-1-carbaldehyde (109, 4.7 g).

1. customSolvents were removed
2. customdried
3. additionPEG (MW 380-420, 53 mL) was added
4. stirringwith stirring over 15 minutes
5. waitThe stirring was continued for another 30 minutes
6. extractionwas extracted with EtOAc three times
7. washThe combined organic layers were washed with water and brine The combined organic layers
8. dry with materialwere dried over MgSO4
9. filtrationfiltered
10. concentrationconcentrated
11. custompurified by flash chromatography (0-40% EtOAc/hexane)

ORD 기록

ord-c27de7f142b945c9a47adb9936caa3f2

출처 데이터셋

uspto-grants-2012_02

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08124607B2