Hydrochloric Acid → [[2-[(4-Acetyl-3-hydroxy-2-propylbenzyl)thio]-pyrimidin-4-yl]oxy]acetic acid
반응식
[C:1]([C:4]1[CH:24]=[CH:23][C:7]([CH2:8][S:9][C:10]2[N:15]=[C:14]([O:16][CH2:17][C:18]([O:20]CC)=[O:19])[CH:13]=[CH:12][N:11]=2)=[C:6]([CH2:25][CH2:26][CH3:27])[C:5]=1[OH:28])(=[O:3])[CH3:2].[OH-].[Na+].C(OCC)(=O)C.Cl>CO>[C:1]([C:4]1[CH:24]=[CH:23][C:7]([CH2:8][S:9][C:10]2[N:15]=[C:14]([O:16][CH2:17][C:18]([OH:20])=[O:19])[CH:13]=[CH:12][N:11]=2)=[C:6]([CH2:25][CH2:26][CH3:27])[C:5]=1[OH:28])(=[O:3])[CH3:2]참가 물질
반응물 4
생성물 1
시약·촉매·용매 1
반응 조건
- 온도
- 60 °C
실험 절차
In 2 ml of 90% methanol was dissolved 0.06 g of ethyl [[2-[(4-acetyl-3-hydroxy-2-propylbenzyl)thio]-pyrimidin-4-yl]oxy]acetate obtained in Example 15 with heating at 60° C. Further 1 ml of a 1N aqueous sodium hydroxide solution was added to the solution followed by stirring at 60° C. for 15 minutes. An aqueous sodium hydroxide solution and ethyl acetate were added to the reaction mixture to fractionate. The aqueous phase was made acidic with 2N hydrochloric acid and extracted with ethyl acetate. The extract was washed with water and then dried over anhydrous magnesium sulfate The solvent was then distilled off. The thus obtained solid was recrystallized from isopropyl alcohol to give 0.02 g of [[2-[(4-acetyl-3-hydroxy-2-propylbenzyl)thio]-pyrimidin-4-yl]oxy]acetic acid.
후처리
- extractionextracted with ethyl acetate
- washThe extract was washed with water
- dry with materialdried over anhydrous magnesium sulfate The solvent
- distillationwas then distilled off
- customThe thus obtained solid was recrystallized from isopropyl alcohol
출처 및 근거
- ORD 기록
- ord-f48ddb74ca1b44448d25295c375dda24
- 출처 데이터셋
- uspto-grants-1993_01
- 특허 번호
- US05180730
반응 노트
불러오는 중…