1,3-Propanedithiol → 2-Fluoroadenine

HRID 1646670

반응식

HRID 1646670 반응식
C(N(CC)CC)C.[N:8]([C:11]1[N:19]=[C:18]([F:20])[N:17]=[C:16]2[C:12]=1[NH:13][CH:14]=[N:15]2)=[N+]=[N-].C(S)CCS>CO>[F:20][C:18]1[N:17]=[C:16]2[C:12]([NH:13][CH:14]=[N:15]2)=[C:11]([NH2:8])[N:19]=1

참가 물질

5

반응물 3

HCID 80131,3-PropanedithiolHCID 8471TriethylamineHCID 198012676-azido-2-fluoro-7H-purine

생성물 1

HCID 127902-Fluoroadenine수율 92.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Triethylamine (0.40 mL) was added via syringe to a solution of 6-azido-2-fluoropurine (0.256 g) and 1,3-propanedithiol (0.29 mL) in methanol (13.5 mL). After 15 minutes the reaction was complete as judged by TLC and a white precipitate had formed. The precipitate was collected by filtration and washed with two 10 mL portions of methanol and then dried to obtain 0.203 g of 2-fluoroadenine, mp>300° C. This material was identical to an authentic sample by TLC, NMR and IR.

후처리

  1. customa white precipitate had formed
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with two 10 mL portions of methanol
  4. customdried

출처 및 근거

ORD 기록
ord-d089e88f144d47ecba88e636713cf25d
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05180824

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