Hydrochloric Acid → 2-Hydroxy-2,4-dichlorophenethyl chloride

HRID 1648854노트

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HRID 1648854 반응식
[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:3]=1[C:4](=O)[CH2:5][Cl:6].[BH4-].[Na+].Cl.[O:16]1CCOCC1>O>[OH:16][C:2]1([Cl:1])[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][CH:3]1[CH2:4][CH2:5][Cl:6]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 202502,2',4'-TrichloroacetophenoneHCID 312751,4-DioxaneHCID 4311764Sodium borohydride2회

생성물 1

HCID 204809262-Hydroxy-2,4-dichlorophenethyl chloride

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 52 g (0.23 m) of 2,4-dichlorophenacyl chloride in 200 ml of dioxane is added 9 g (0.24 m) of sodium borohydride dissolved in 60 ml of water dropwise at 50°. The addition is set at such a rate that the reaction temperature does not exceed 50°. After the addition, the reaction mixture is stirred at 50° for 11/2 hours. Excess sodium borohydride is carefully decomposed by slow addition of 10% hydrochloric acid. The organic product is extracted into ether and the combined ether extracts are washed with water, saturated sodium bicarbonate solution, and dried over MgSO4. Solvent is evaporated to give 49 g of product.

후처리

  1. additionThe addition
  2. customdoes not exceed 50°
  3. additionAfter the addition
  4. extractionThe organic product is extracted into ether
  5. washthe combined ether extracts are washed with water, saturated sodium bicarbonate solution
  6. dry with materialdried over MgSO4
  7. customSolvent is evaporated

출처 및 근거

ORD 기록
ord-3b15a04a550c492d9fb066297dfcea73
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04414210

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