Chloroacetyl chloride → 5-(Chloroacetyl)-8-hydroxy-2(1H)-quinolinone

HRID 1649008노트

반응식

HRID 1649008 반응식
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH:8]=[CH:7]2.[Cl:13][CH2:14][C:15](Cl)=[O:16].[Cl-].[Al+3].[Cl-].[Cl-].[N+](C1C=CC=CC=1)([O-])=O>Cl>[Cl:13][CH2:14][C:15]([C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9](=[O:12])[NH:10]2)=[O:16]

참가 물질

6

반응물 4

HCID 6577Chloroacetyl chlorideHCID 7416NitrobenzeneHCID 972508-hydroxyquinolin-2(1H)-oneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 132602995-(Chloroacetyl)-8-hydroxy-2(1H)-quinolinone

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
70 °C

실험 절차

To a solution of 8-hydroxycarbostyril (27 g) and chloroacetyl chloride (37 ml) in ntirobenzene (250 ml) was added aluminum chloride (85 g) portionwise and the mixture was stirred at 70° C. for 20 hours. After adding 10% hydrochloric acid (500 ml), nitrobenzene was removed by steam distillation. After cooling, crystals which formed were collected by filtration, washed with 300 ml of hot water and recrystallized from methanol to give 4.0 g of 5-chloroacetyl-8-hydroxycarbostyril.

후처리

  1. customwas removed by steam distillation
  2. temperatureAfter cooling
  3. customcrystals which formed
  4. filtrationwere collected by filtration
  5. washwashed with 300 ml of hot water
  6. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-9044843f8cda477f8220d25a01ba982a
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04414390

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