Sodium Hydroxide → 8-Aminoquinolin-2(1H)-one

HRID 1649206노트

반응식

HRID 1649206 반응식
C([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]=[CH:10]2)(=O)C.[OH-].[Na+]>Cl>[NH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]=[CH:10]2

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 13317110HCID 13317110, 화합물

생성물 1

HCID 133171128-Aminoquinolin-2(1H)-one수율 91.1%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

8-Acetylaminocarbostyril (21.5 g, 0.106 mol) was suspended in 190 ml of 20% hydrochloric acid and the suspension was stirred while heating under reflux for 1 hour. The reaction mixture was poured into ice water and neutralized with 5 N sodium hydroxide. Crystals which formed were collected by filtration to give 15.47 g of 8-aminocarbostyril.

후처리

  1. temperaturewhile heating
  2. temperatureunder reflux for 1 hour
  3. customCrystals which formed
  4. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-6d38258e6bc741be942b36a5bb376208
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04415572

반응 노트

불러오는 중…