Sodium Acetate → 1-(2-Aminothiazol-4-yl)-1-propencarboxylic acid ethyl ester

HRID 1649413

반응식

HRID 1649413 반응식
[CH2:1]([O:3][C:4](=[O:12])[C:5](=[CH:10][CH3:11])[C:6](=O)[CH2:7]Cl)[CH3:2].C([O-])(=O)C.[Na+].[NH2:18][C:19]([NH2:21])=[S:20]>O1CCCC1.O>[CH2:1]([O:3][C:4]([C:5]([C:6]1[N:18]=[C:19]([NH2:21])[S:20][CH:7]=1)=[CH:10][CH3:11])=[O:12])[CH3:2]

참가 물질

6

반응물 3

HCID 517045Sodium AcetateHCID 2723790ThioureaHCID 54518096Ethyl 2-ethylidene-4-chloro-3-oxobutyrate

생성물 1

HCID 544043711-(2-Aminothiazol-4-yl)-1-propencarboxylic acid ethyl ester

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

to a solution of 190 g of the product of example 81 in 400 ml tetrahydrofuran were added first a solution of 82 g sodium acetate in 150 ml of water and then 76 g thiourea. The solution was stirred at room temperature for 20 hours, then the THF was distilled off and acetic acid ethyl ester was added to the residue.

후처리

  1. distillationthe THF was distilled off
  2. additionacetic acid ethyl ester was added to the residue

출처 및 근거

ORD 기록
ord-9b4705d37edf4c80b2ad9f87b172ad31
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04416880

연결된 노트

불러오는 중…