Hydrochloric Acid → HCID 15077478, 화합물

HRID 1650882

반응식

HRID 1650882 반응식
[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([CH3:14])=[C:7]([CH:13]=1)[C:8]([O:10]CC)=[O:9])[CH3:2].[OH-].[Na+].Cl>CO.O>[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([CH3:14])=[C:7]([CH:13]=1)[C:8]([OH:10])=[O:9])[CH3:2]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 144366265-Ethyl-2-methyl-nicotinic acid ethyl ester

생성물 1

HCID 15077478HCID 15077478, 화합물수율 1.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of 260 g of ethyl 5-ethyl-2-methylnicotinate 81.34 mol) in 250 mL methanol is treated in 1 portion with a solution of 80 g of sodium hydroxide (2 mol) in 1 L water. The reaction is stirred at room temperature for 2 days, then concentrated in vacuo to a volume of about 700 mL, and acidified with 167 mL of concentrated hydrochloric acid (2 moles). The precipitated solid is filtered, washed with cold water, and dried in vacuo at 75° C. to afford 184 g of the title product, mp 218°-220° C.

후처리

  1. concentrationconcentrated in vacuo to a volume of about 700 mL
  2. filtrationThe precipitated solid is filtered
  3. washwashed with cold water
  4. customdried in vacuo at 75° C.

출처 및 근거

ORD 기록
ord-8d9cb089dd3d4958bbc5ae0ad6629a77
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04925944

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