Hydrochloric Acid → 7-demethylmitomycin A

HRID 1651308

반응식

HRID 1651308 반응식
[CH3:1][C:2]1[C:8](=[O:9])[C:7]2[N:10]3[C@@:14]([O:21][CH3:22])([C@H:15]([CH2:16][O:17][C:18]([NH2:20])=[O:19])[C:6]=2[C:4](=[O:5])[C:3]=1N)[C@H:13]1[NH:23][C@H:12]1[CH2:11]3.Cl.CCCCCC.[OH-:32].[Na+]>CCOCC>[CH3:1][C:2]1[C:3](=[O:32])[C:4](=[O:5])[C:6]2[C@@H:15]([CH2:16][O:17][C:18]([NH2:20])=[O:19])[C@@:14]3([O:21][CH3:22])[C@H:13]4[NH:23][C@H:12]4[CH2:11][N:10]3[C:7]=2[C:8]=1[OH:9]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 5746Mitomycin CHCID 8058HexaneHCID 14798Sodium Hydroxide

생성물 1

HCID 117273937-demethylmitomycin A수율 63%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Mitomycin C (2.2 g, 6.6 mmoles) was dissolved in 140 ml 0.1N methanolic NaOH (50%) and the reaction mixture was stirred at room temperature for 30 hours. The solution was then adjusted to ca. pH 4.0 with 1N HCl and extracted with ethyl acetate (4×500 ml). The combined ethyl acetate extracts were dried (Na2SO4) and evaporated under reduced pressure at about 30° to 35° C. to obtain a solid residue, which upon dissolving in ether and treating with excess hexane afforded a purple precipitate. The precipitate was collected and air dried to afford the title compound as a fine purple powder (1.4 g, 63%).

후처리

  1. extractionextracted with ethyl acetate (4×500 ml)
  2. dry with materialThe combined ethyl acetate extracts were dried (Na2SO4)
  3. customevaporated under reduced pressure at about 30° to 35° C.
  4. customto obtain a solid residue, which
  5. customafforded a purple precipitate
  6. customThe precipitate was collected
  7. customair dried

출처 및 근거

ORD 기록
ord-8365ec66c8744729a94a44f73a5f0f5f
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04927943

연결된 노트

불러오는 중…