Acetic Anhydride → HCID 86743970, 화합물

HRID 1651581노트

반응식

HRID 1651581 반응식
[C:1]([NH:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17](=[O:24])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:12]([F:25])[CH:11]=2)[CH2:6]1)(=[O:3])[CH3:2].[CH:26](OCC)(OCC)[O:27][CH2:28][CH3:29].C(OC(=O)C)(=O)C>>[C:1]([NH:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17](=[O:24])[C:18](=[CH:26][O:27][CH2:28][CH3:29])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:12]([F:25])[CH:11]=2)[CH2:6]1)(=[O:3])[CH3:2]

참가 물질

4

반응물 3

HCID 7918Acetic AnhydrideHCID 31214Ethyl orthoformateHCID 14770849HCID 14770849, 화합물

생성물 1

HCID 86743970HCID 86743970, 화합물

실험 절차

A solution of 17.7 g (50 mmol) of 4-[3-(acetylamino)cyclopentyl]-2,5-difluoro-β-oxobenzenepropanoic acid, ethyl ester, 11.1 g (75 mmol) triethyl orthoformate and 75 ml of acetic anhydride was refluxed for 3 hours. The solvent was removed in vacuo and the residue triturated with toluene which was also removed in vacuo, then in high vacuo at 50°. The residue, 20.1 g, was used without further purification.

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue triturated with toluene which
  3. customwas also removed in vacuo
  4. customat 50°
  5. customThe residue, 20.1 g, was used without further purification

출처 및 근거

ORD 기록
ord-23fe9ec554094c6f81ecd160c56a9471
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04929613

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