Water → HCID 20077451, 화합물

HRID 1655022노트

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HRID 1655022 반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:8][C:9](=[O:13])[NH:10]2)=[CH:5][CH:4]=1.[H-].[Na+].[CH3:22]I.O>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:8][C:9](=[O:13])[N:10]2[CH3:22])=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 7227187-methoxy-4-phenyl-quinolin-2-ol

생성물 1

HCID 20077451HCID 20077451, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
50 °C

실험 절차

A solution of 7-methoxy-4-phenyl-2-quinolinone from Example 1, Step 2 (1.62 g) in DMF (30 mL) was treated with NaH (60% in mineral oil; 310 mg). After stirring at 50° C. for 45 min., the mixture was cooled to r.t. and methyl iodide (0.6 mL) was added. After 30 min., H2O (100 mL) was added and the resulting solution extracted with EtOAc (3×). The organics were washed with H2O (2×), brine, dried (MgSO4) and the solvents evaporated. Flash chromatography of the residue (silica gel; CHCl3 /EtOAc (4:1)) provided the title compound as a foam.

후처리

  1. temperaturethe mixture was cooled to r.t.
  2. waitAfter 30 min.
  3. extractionthe resulting solution extracted with EtOAc (3×)
  4. washThe organics were washed with H2O (2×), brine
  5. dry with materialdried (MgSO4)
  6. customthe solvents evaporated

출처 및 근거

ORD 기록
ord-c8004835cb9f40c5a304476917eda2f1
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05410054

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