Water → 1-Dimethylsulfamoyl-2-ethylimidazole
반응식
[CH2:1]([C:3]1[NH:4][CH:5]=[CH:6][N:7]=1)[CH3:2].C(N(CC)CC)C.[CH3:15][N:16]([CH3:21])[S:17](Cl)(=[O:19])=[O:18].O>C(Cl)(Cl)Cl>[CH3:15][N:16]([CH3:21])[S:17]([N:4]1[CH:5]=[CH:6][N:7]=[C:3]1[CH2:1][CH3:2])(=[O:19])=[O:18]참가 물질
6
실험 절차
To a stirred solution of 2-ethylimidazole (100 g) and triethylamine (115 g) in chloroform (800 ml) at 0° C. is added a solution of dimethylsulfamoyl chloride (153 g) in chloroform (200 ml). The mixture is stirred overnight at room temperature. Water (1.5 liter) is added to the reaction mixture after which the organic layer is separated and concentrated. The residue is dissolved in ethyl acetate (1 liter) and washed with water, and then dried over sodium sulfate and concentrated. Distillation gives 1-dimethylsulfamoyl-2 -ethylimidazole (182 g) as a colorless liquid.
후처리
- customis separated
- concentrationconcentrated
- dissolutionThe residue is dissolved in ethyl acetate (1 liter)
- washwashed with water
- dry with materialdried over sodium sulfate
- concentrationconcentrated
- distillationDistillation
출처 및 근거
- ORD 기록
- ord-266522fce9ce4785a5f23b6ab5a6afdb
- 출처 데이터셋
- uspto-grants-1995_04
- 특허 번호
- US05409936
반응 노트
불러오는 중…