Benzylamine → n-Benzyl-2-hydroxyacetamide

HRID 1655364

반응식

HRID 1655364 반응식
C[O:2][C:3](=O)[CH2:4][OH:5].[CH2:7]([NH2:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[CH2:7]([NH:14][C:3](=[O:2])[CH2:4][OH:5])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

3

반응물 2

HCID 7504BenzylamineHCID 66774Methyl Glycolate

생성물 1

HCID 231065n-Benzyl-2-hydroxyacetamide

실험 절차

The procedure of 84A was followed with methyl2-hydroxyethanoate (8 g) and benzylamine (10 ml in 30 ml H2O). After one hour material precipitated out of solution. The mixture was stirred overnight, and the solid recovered by filtration to provide 4.12 g of white solid. The solvent was removed from the filtrate by vacuum to provide 4.71 g of material The solid and filtrate were combined and passed over a silica column eluting with a gradient of ethyl acetate to ethyl acetate/methanol (v:v, 1:1). Removal of solvent provided 8 g of white crystal product.

후처리

  1. customAfter one hour material precipitated out of solution
  2. filtrationthe solid recovered by filtration

출처 및 근거

ORD 기록
ord-ec00d9d880564a899597fddd08833cd4
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250542

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