Sulfuric Acid → 2-(Furan-2-yl)-3-methylbutanoic acid

HRID 1655760노트

반응식

HRID 1655760 반응식
C([O:3][C:4](=[O:19])[C:5]([C:14]1[O:15][CH:16]=[CH:17][CH:18]=1)([CH:11]([CH3:13])[CH3:12])C(OCC)=O)C.[OH-].[Na+].S(=O)(=O)(O)O>CS(C)=O>[O:15]1[CH:16]=[CH:17][CH:18]=[C:14]1[CH:5]([CH:11]([CH3:13])[CH3:12])[C:4]([OH:19])=[O:3]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 536718092-Furyl-2-isopropylmalonic acid diethyl ester

생성물 1

HCID 197908462-(Furan-2-yl)-3-methylbutanoic acid수율 98.2%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

240.6 g (0.9 mol) of 2-furyl-2-isopropylmalonic acid diethyl ester were dissolved in 500 ml of dimethyl sulfoxide, treated with 2000 ml of 2N sodium hydroxide solution and heated to reflux for 2 hours. After cooling, o the reaction mixture was poured into dilute sulfuric acid and extracted exhaustively with ether. The organic extracts were thereafter dried and the solvent was evaporated under reduced pressure, to obtain 148.7 g (98%) of (±) 2-(2-furyl)-3-methyl- butyric acid in the form of a thick yellowish oil.

후처리

  1. temperatureheated
  2. temperatureto reflux for 2 hours
  3. temperatureAfter cooling, o the reaction mixture
  4. extractionextracted exhaustively with ether
  5. customThe organic extracts were thereafter dried
  6. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-b414730056a548e08079aab95ebcceec
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250517

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