Hydrochloric Acid → HCID 18954726, 화합물
반응식
C([NH:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)=[CH:8][N:9]=1)(=O)C.Cl.[OH-].[Na+]>C(O)(=O)C>[NH2:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)=[CH:8][N:9]=1참가 물질
5
실험 절차
A solution of 2-acetylamino-5-(4-aminophenylthio)thiazole (2.5 g) in a mixture of acetic acid (20 ml) and 6N-aqueous hydrochloric acid (5 ml) was refluxed for 4 hours with stirring. The reaction mixture was poured into ice-water and the solution was adjusted to pH 10 using 1N-aqueous sodium hydroxide with stirring under ice cooling. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-amino-5-(4-aminophenylthio)thiazole (1.70 g, yield: 81.5%).
후처리
- temperaturewas refluxed for 4 hours
- stirringwith stirring under ice cooling
- filtrationThe precipitates were collected by filtration
- washwashed with water
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-6ac500995a7b4ee8b13922b1cc89d9dc
- 출처 데이터셋
- uspto-grants-1993_10
- 특허 번호
- US05256675
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