2-Amino-2-methyl-1,3-propanediol → HCID 21414467, 화합물
반응식
[CH:1]1([C:7]#[N:8])[CH2:4][CH2:3][CH:2]1[C:5]#[N:6].[OH:9][CH2:10][C:11](N)([CH3:14])[CH2:12][OH:13]>Cl[Cu]>[CH3:14][C:11]1([CH2:12][OH:13])[CH2:10][O:9][C:5]([CH:2]2[CH2:3][CH2:4][CH:1]2[C:7]2[O:9][CH2:10][C:11]([CH2:12][OH:13])([CH3:14])[N:8]=2)=[N:6]1참가 물질
4
실험 절차
53 g of cyclobutane-1,2-dinitrile were heated for 3.5 hours to 100°C with 150 g of 2-hydroxymethyl-2-amino-1-propanol in the presence of 0.5 g of CuCl. Distillation of the reaction mixture in the same way as described in Example 15 gave 175 g of distillate boiling at 142° - 200°C/0.6 Torr which, when subsequently fractionated in a Vigreux column, gave 117 g (83% of the theoretical) of 1,2-bis-(4-methyl-4-hydroxymethyl oxazolin-2-yl)-cyclobutane boiling at 198° - 204°C/0.05 Torr.
후처리
- distillationDistillation of the reaction mixture in the same way
- customgave 175 g of distillate boiling at 142° - 200°C/0.6 Torr which, when
출처 및 근거
- ORD 기록
- ord-fdf882d6ad90479c89dd5f037b6802b7
- 출처 데이터셋
- uspto-grants-1976_06
- 특허 번호
- US03962270
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