Benzene, (trichloromethoxy)- → 2,4,5-Trichlorophenol

반응식

[Cl-:1].[Al+3].[Cl-:3].[Cl-:4].ClC(Cl)(Cl)[O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[Cl:1][C:9]1[CH:10]=[C:11]([Cl:3])[C:12]([Cl:4])=[CH:13][C:8]=1[OH:7]

참가 물질

반응물 2

HCID 40773Benzene, (trichloromethoxy)-

HCID 6451240Aluminum(III) Chloride

생성물 1

HCID 72712,4,5-Trichlorophenol수율 24%

실험 절차

Although aluminium chloride is a member of the class of Lewis acids, other Lewis acids have not been found effective or useful in the process of the invention. Ferric chloride did not effect significant demethylation. Only a 24% yield of 2,4,5-trichlorophenol was obtained when trichloroanisole was treated with a large excess of concentrated sulphuric acid for six hours at 75° C. in the absence of solvent. Other Lewis acids, viz. boron trichloride, boron trifluoride and pyridinium hydrochloride, are not economically attractive for this use. Thus aluminium trichloride is preferred as the demethylating agent.

출처 및 근거

ORD 기록: ord-f3ffc86da4fa4906a405f2dbfc8ddc72
출처 데이터셋: uspto-grants-1981_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04306098

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