Hydrochloric Acid → 2-(3,5-Dioxo-1,2,4-triazolidin-4-yl)acetic acid

반응식

[O:1]=[C:2]1[N:6]([CH2:7][C:8]([O:10]C)=[O:9])[C:5](=[O:12])[NH:4][NH:3]1.[OH-].[Na+].Cl>>[O:1]=[C:2]1[N:6]([CH2:7][C:8]([OH:10])=[O:9])[C:5](=[O:12])[NH:4][NH:3]1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 14798Sodium Hydroxide

HCID 53759869Methyl 3,5-dioxo-1,2,4-triazolidine-4-acetate

생성물 1

HCID 205575302-(3,5-Dioxo-1,2,4-triazolidin-4-yl)acetic acid수율 33%

실험 절차

0.5 g (2.9 mmol) of methyl 3,5-dioxo-1,2,4-triazolidine-4-acetate was stirred at room temperature for 2 hours with 8.7 ml (8.7 mmol) of 1-M sodium hydroxide solution. The resulting solution was acidified with concentrated hydrochloric acid and evaporated to dryness. The solid residue was extracted with hot acetonitrile. The acetonitrile extracts were evaporated and the residual colourless solid was recrystallized from acetonitrile, there being obtained 0.15 g (33%) of 3,5-dioxo-1,2,4-triazolidine-4-acetic acid of melting point 220°-223° C. (from acetonitrile).

후처리

customevaporated to dryness
extractionThe solid residue was extracted with hot acetonitrile
customThe acetonitrile extracts were evaporated
customthe residual colourless solid was recrystallized from acetonitrile, there

출처 및 근거

ORD 기록: ord-75b26e5952c944288a2a8754a147d2d3
출처 데이터셋: uspto-grants-1981_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04307094

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