Ethyl Acetate → 5-Nitro-N-(2-oxo-ethyl)-isophthalamic acid methyl ester

HRID 1664208

반응식

HRID 1664208 반응식
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[C:6]([C:7]([NH:9][CH2:10][CH:11](OC)[O:12]C)=[O:8])[CH:5]=1.C(OCC)(=O)C>C1COCC1.Cl>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[C:6]([C:7]([NH:9][CH2:10][CH:11]=[O:12])=[O:8])[CH:5]=1

참가 물질

5

반응물 2

HCID 8857Ethyl AcetateHCID 67439609N-(2,2-dimethoxy-ethyl)-5-nitro-isophthalamic acid methyl ester

생성물 1

HCID 866265795-Nitro-N-(2-oxo-ethyl)-isophthalamic acid methyl ester

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 29.7 g (95.1 mmol) of N-(2,2-dimethoxy-ethyl)-5-nitro-isophthalamic acid methyl ester in 300 ml of THF and 300 ml of 2N HCl is stirred overnight. Ethyl acetate is added, and the mixture is washed twice with brine. The organic phase is dried over sodium sulfate and evaporated to yield the product in the form of a yellow oil.

후처리

  1. washthe mixture is washed twice with brine
  2. dry with materialThe organic phase is dried over sodium sulfate
  3. customevaporated
  4. customto yield the product in the form of a yellow oil

출처 및 근거

ORD 기록
ord-1612f793da6a4beda7e6ce3a5b6b8e03
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039455B2

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