3-Chlorobenzenesulphonyl chloride → N-(5-bromo-thiophen-2-ylmethyl)-3-chloro-benzenesulfonamide

HRID 1665015

반응식

HRID 1665015 반응식
[Br:1][C:2]1[S:6][C:5]([CH2:7][NH2:8])=[CH:4][CH:3]=1.[Cl:9][C:10]1[CH:11]=[C:12]([S:16](Cl)(=[O:18])=[O:17])[CH:13]=[CH:14][CH:15]=1.C(N(CC)C(C)C)(C)C>ClCCl>[Br:1][C:2]1[S:6][C:5]([CH2:7][NH:8][S:16]([C:12]2[CH:13]=[CH:14][CH:15]=[C:10]([Cl:9])[CH:11]=2)(=[O:18])=[O:17])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 179093-Chlorobenzenesulphonyl chlorideHCID 81531DiisopropylethylamineHCID 23130577(5-Bromothiophen-2-yl)methanamine

생성물 1

HCID 35408893N-(5-bromo-thiophen-2-ylmethyl)-3-chloro-benzenesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In analogy to example 4, step 1, 1-(5-bromo-2-thienyl)methanamine was reacted with 3-chlorobenzenesulfonyl chloride and N,N-diisopropyl ethyl amine in dichloromethane to give N-(5-bromo-thiophen-2-ylmethyl)-3-chloro-benzenesulfonamide as a colorless solid. MS: 363.9 ([M−H]−)

출처 및 근거

ORD 기록
ord-56badee85d834d08b71575581cd23efe
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039493B2

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