2-Chlorobenzenesulfonyl chloride → N-(2-bromo-thiazol-5-ylmethyl)-2-chloro-benzenesulfonamide

HRID 1665020

반응식

HRID 1665020 반응식
Cl.[Br:2][C:3]1[S:4][C:5]([CH2:8][NH2:9])=[CH:6][N:7]=1.[Cl:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17](Cl)(=[O:19])=[O:18].C(N(CC)C(C)C)(C)C>ClCCl>[Br:2][C:3]1[S:4][C:5]([CH2:8][NH:9][S:17]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[Cl:10])(=[O:19])=[O:18])=[CH:6][N:7]=1

참가 물질

5

반응물 3

HCID 761872-Chlorobenzenesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 71434973c-(2-Bromo-thiazol-5-yl)-methylamine hydrochloride

생성물 1

HCID 67441135N-(2-bromo-thiazol-5-ylmethyl)-2-chloro-benzenesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In analogy to example 1, step 1, 2-bromo-5-aminomethyl-thiazole hydrochloride was reacted with 2-chlorobenzenesulfonylchloride and N,N-diisopropyl ethyl amine in dichloromethane to give N-(2-bromo-thiazol-5-ylmethyl)-2-chloro-benzenesulfonamide as an off-white solid. MS: 367.0 ([M+H]+)

출처 및 근거

ORD 기록
ord-7059e3810b764eb084d30660e5b914c0
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039493B2

연결된 노트

불러오는 중…