Propylparaben → Florfenicol Flunixin

HRID 1666774

반응식

HRID 1666774 반응식
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C@@H:11]([OH:21])[C@H:12]([NH:15][C:16]([CH:18]([Cl:20])[Cl:19])=[O:17])[CH2:13][F:14])=[CH:9][CH:10]=1)(=[O:4])=[O:3].COC(C1C=CC(O)=CC=1)=O.OC1C=CC(C(OCCC)=O)=CC=1.[CH3:46][C:47]1[C:52]([NH:53][C:54]2[N:59]=[CH:58][CH:57]=[CH:56][C:55]=2[C:60]([OH:62])=[O:61])=[CH:51][CH:50]=[CH:49][C:48]=1[C:63]([F:66])([F:65])[F:64].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>O.CN1C(=O)CCC1>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C@@H:11]([OH:21])[C@H:12]([NH:15][C:16]([CH:18]([Cl:20])[Cl:19])=[O:17])[CH2:13][F:14])=[CH:9][CH:10]=1)(=[O:4])=[O:3].[CH3:46][C:47]1[C:52]([NH:53][C:54]2[N:59]=[CH:58][CH:57]=[CH:56][C:55]=2[C:60]([OH:62])=[O:61])=[CH:51][CH:50]=[CH:49][C:48]=1[C:63]([F:65])([F:64])[F:66]

참가 물질

7

반응물 4

HCID 7175PropylparabenHCID 7456MethylparabenHCID 39212Flunixin MeglumineHCID 114811Florfenicol

생성물 1

HCID 86602307Florfenicol Flunixin

시약·촉매·용매 2

HCID 962Water용매HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

The NMP and a portion of the polyethylene glycol 200 are charged to the compounding vessel. Florfenicol, methyl p-hydroxybenzoate and propyl p-hydroxybenzoate are added to the vessel and mixed until dissolved. Water is added, followed by the flunixin meglumine, and mixed until solids are dissolved. Q.S. to final volume with polyethylene glycol 200 if needed.

후처리

  1. additionmixed
  2. dissolutionuntil dissolved
  3. additionmixed until solids
  4. dissolutionare dissolved

출처 및 근거

ORD 기록
ord-5e5b3578ea0e4423a422053af5371a76
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044102B2

연결된 노트

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