Flunixin Meglumine
기본 정보
- CAS
42461-84-7- 표준 SMILES
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F- InChIKey
MGCCHNLNRBULBU-WZTVWXICSA-N- 분자식
- C21H28F3N3O7
- 평균 분자량
- 491.5 g/mol
개요
Flunixin meglumine is an organoammonium salt obtained by combining flunixin with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine for treatment of horses, cattle and pigs. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It contains a flunixin(1-).
이름 및 식별자
- 우선 이름
- Flunixin Meglumine
- IUPAC
- (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol;2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
- 영어명
- Flunixin Meglumin
- 분자식
- C14H11F3N2O2.C7H17NO5
- 분자량
- 491.46
이름 및 동의어
FLUNIXIN MEGLUMINE42461-84-7BanamineFlumeglumineSch 14714 meglumineFlunixin-SFlunixin N-methylglucanineSch-14714 meglumine8Y3JK0JW3UFlunixin meglumine saltFlunazineNSC-759583
이름 더 보기
flunixin megluminFlunixin Meglunine1-deoxy-1-(methylamino)-d-glucito2-((2-methyl-3-(trifluoromethyl)phenyl)amFinadyneEquileveNIH 10250fluixi egluieIliuM Flunixil
CHEBI:761442-((2-Methyl-3-(trifluoromethyl)-phenyl)amino)-3-pyridinecarboxylic acid with meglumine compoundedDTXCID9025584FlunineVetaMegBanamine PasteFlunazine-SVetameg S
데이터베이스 식별자
- CAS
42461-84-7- PubChem CID
- 39212
- ChEMBL
CHEMBL1733447- ChEBI
물성
구조 계산 물성
- 극성 표면적
- 175 Ų
- 수소 결합 공여자 수
- 8
- 수소 결합 수용자 수
- 13
- 회전 가능 결합 수
- 9
- 무거운 원자 수
- 34
- 형식 전하
- 0
- 복잡도
- 510
실험 및 물리화학적 성질
DrugsDEA NFLIS-Drug Category -> Analgesics
Animal DrugsActive Ingredients (Flunixin Meglumine) -> FDA Greenbook
물리화학적 성질
- 녹는점
- 136.6 · 136.6-137.4 °C
- 저장 조건
- room temp
- 용해도
- 2 O: · H2O: 자유롭게 용해됨
- 물리적 상태
- 고체
- 색상
- 회백색
- 수용성
- 녹는
- InChIKey
- MGCCHNLNRBULBU-WZTVWXICSA-N
- SMILES
- CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F
화학적 성질
White Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 0.5% (1 of 215) of reports.
Danger
H301 (79.5%): Toxic if swallowed [Danger Acute toxicity, oral]
P260, P261, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P320, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 215 reports by companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory InformationFlunixin meglumine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - D-Glucitol, 1-deoxy-1-(methylamino)-, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylate (salt): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (79.5%)
안전 데이터
- wgk
- 3
- rtecs
- LZ4367000
- ridadr
- UN 2811 6.1 / PGI
- HS 번호
- 29339900
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
- 스토리지 클래스
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Drugs that are used to reduce body temperature in fever.
용도 및 제조
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
응용 분야
용도Flunixin meglumine has been used as a nonsteroidal anti-inflammatory drug standard in electrospray ionization mass spectrometry (LC-ESI/MS).
일반 설명Flunixin meglumine is a nonsteroidal anti-inflammatory drug and a potent cyclo-oxygenase (COX) inhibitor. It is commonly used as an analgesic and antipyretic in animals.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
추가 설명
정의ChEBI: An organoammonium salt obtained by combining flunixin with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic propert es; used in veterinary medicine for treatment of horses, cattle and pigs.
관련 반응
9건
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