Flunixin Meglumine

HCID 39212CAS 42461-84-7

기본 정보

표준 SMILES: CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F
InChIKey: MGCCHNLNRBULBU-WZTVWXICSA-N
분자식: C21H28F3N3O7
평균 분자량: 491.5 g/mol

개요

Flunixin meglumine is an organoammonium salt obtained by combining flunixin with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine for treatment of horses, cattle and pigs. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It contains a flunixin(1-).

이름 및 식별자

우선 이름: Flunixin Meglumine
IUPAC: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol;2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid

이름 및 동의어

FLUNIXIN MEGLUMINE42461-84-7BanamineFlumeglumineSch 14714 meglumineFlunixin-SFlunixin N-methylglucanineSch-14714 meglumine8Y3JK0JW3UFlunixin meglumine saltFlunazineNSC-759583

이름 더 보기

CHEBI:761442-((2-Methyl-3-(trifluoromethyl)-phenyl)amino)-3-pyridinecarboxylic acid with meglumine compoundedDTXCID9025584FlunineVetaMegBanamine PasteFlunazine-SVetameg S

데이터베이스 식별자

CAS: 42461-84-7
PubChem CID: 39212
ChEMBL: CHEMBL1733447
ChEBI: CHEBI:76144
UNII: 8Y3JK0JW3U
EC Number: 255-836-0

물성

구조 계산 물성

극성 표면적: 175 Å²
수소 결합 공여자 수: 8
수소 결합 수용자 수: 13
회전 가능 결합 수: 9
무거운 원자 수: 34
형식 전하: 0
복잡도: 510

실험 및 물리화학적 성질

DrugsDEA NFLIS-Drug Category -> Analgesics

Animal DrugsActive Ingredients (Flunixin Meglumine) -> FDA Greenbook

안전 및 규제

GHS 분류

GHS Classification · 5건

This chemical does not meet GHS hazard criteria for 0.5% (1 of 215) of reports.

Danger

H301 (79.5%): Toxic if swallowed [Danger Acute toxicity, oral]

P260, P261, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P320, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 215 reports by companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory InformationFlunixin meglumine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - D-Glucitol, 1-deoxy-1-(methylamino)-, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylate (salt): Environment tier I assessment

Hazard Classes and CategoriesAcute Tox. 3 (79.5%)

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 2건

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Drugs that are used to reduce body temperature in fever.