Acetone → Olanzapine

HRID 1666933노트

반응식

HRID 1666933 반응식
[NH2:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[NH:4][C:5]1[S:6][C:7]([CH3:12])=[CH:8][C:9]=1[C:10]#[N:11].Cl.CC(C)=O.C.[CH3:23][N:24]1[CH2:29][CH2:28]N[CH2:26][CH2:25]1>>[CH3:12][C:7]1[S:6][C:5]2[NH:4][C:3]3[CH:13]=[CH:14][CH:15]=[CH:16][C:2]=3[N:1]=[C:10]([N:11]3[CH2:28][CH2:29][N:24]([CH3:23])[CH2:25][CH2:26]3)[C:9]=2[CH:8]=1

참가 물질

6

반응물 5

HCID 180AcetoneHCID 297MethaneHCID 313Hydrochloric AcidHCID 531671-Methylpiperazine2회HCID 674452622-(2-Aminoanilino)-5-methylthiophene-3-carbonitrile

생성물 1

HCID 135398745Olanzapine

반응 조건

온도
120 °C

실험 절차

2-(2-Aminoanilino)-5-methylthiophene-3-carbonitrile (2.0 g) is taken in N-methyl-piperazine (12 ml) and N-methyl piperazine.HCl (4.6 g). The solution is heated at 120° C. until completion of reaction. The reaction mass is cooled to 70-75° C. and acetone and activated charcoal are added. The reaction mixture is stirred for 30 minutes and filtered. The water is added at 45-50° C., the mixture is cooled up to room temperature and the precipitated solid is filtered off and washed with acetone-water mixture.

후처리

  1. temperatureThe reaction mass is cooled to 70-75° C.
  2. filtrationfiltered
  3. additionThe water is added at 45-50° C.
  4. temperaturethe mixture is cooled up to room temperature
  5. filtrationthe precipitated solid is filtered off
  6. washwashed with acetone-water mixture

출처 및 근거

ORD 기록
ord-319ceafb4bca4fd287bd24c62bcc3a2d
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044196B2

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