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Triethylamine → 6-(4-fluorophenyl)-3-{2-[4-(1-pyrrolidin-1-ylethyl)phenyl]ethyl}thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

HRID 1668399
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HRID 1668399 반응식
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[S:4][C:3]=1[C:14]([NH:16][CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH:25]([N:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)[CH3:26])=[CH:21][CH:20]=1)=[O:15].C(N(CC)CC)C.Cl[C:40](Cl)([O:42]C(=O)OC(Cl)(Cl)Cl)Cl.N1CCCC1>ClCCCl.C(OCC)(=O)C>[F:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[S:4][C:3]3[C:14](=[O:15])[N:16]([CH2:17][CH2:18][C:19]4[CH:24]=[CH:23][C:22]([CH:25]([N:27]5[CH2:31][CH2:30][CH2:29][CH2:28]5)[CH3:26])=[CH:21][CH:20]=4)[C:40](=[O:42])[NH:1][C:2]=3[CH:6]=2)=[CH:8][CH:9]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 31268PyrrolidineHCID 94429TriphosgeneHCID 673594643-amino-5-(4-fluorophenyl)-N-{2-[4-(1-pyrrolidin-1-ylethyl)phenyl]ethyl}thiophene-2-carboxamide

생성물 1

HCID 592398686-(4-fluorophenyl)-3-{2-[4-(1-pyrrolidin-1-ylethyl)phenyl]ethyl}thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione수율 19.2%

시약·촉매·용매 2

HCID 111,2-Dichloroethane용매HCID 8857Ethyl Acetate용매

실험 절차

The obtained 3-amino-5-(4-fluorophenyl)-N-{2-[4-(1-pyrrolidin-1-ylethyl)phenyl]ethyl}thiophene-2-carboxamide (0.15 g) was suspended in 1,2-dichloroethane (5 ml), and triethylamine (0.067 ml) and triphosgene (0.080 g) were successively added with stirring. After 3 hr, pyrrolidine (0.8 ml) was added, and the reaction mixture was stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by column chromatography (hexane:ethyl acetate=9:1 (volume ratio)→1:2 (volume ratio)) using NH-silica gel, and further recrystallized from ethyl acetate to give the title compound (0.024 g) as pale-yellow crystals.

후처리

  1. stirringthe reaction mixture was stirred overnight at room temperature
  2. washwashed with water and saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was purified by column chromatography (hexane
  6. customfurther recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-3ef1295ccde44e2a85f5f453d428fbc3
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07989445B2

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