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Hydrochloric Acid → 3-{4-[1-(4'-Isopropyl-2-methyl-biphenyl-4-yl)-5-methyl-hexyloxy]-benzoylamino}-propionic acid

HRID 1669332
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인쇄 미리보기

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HRID 1669332 반응식
C[O:2][C:3](=[O:39])[CH2:4][CH2:5][NH:6][C:7](=[O:38])[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH:15]([C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][C:31]([CH:34]([CH3:36])[CH3:35])=[CH:30][CH:29]=3)=[C:24]([CH3:37])[CH:23]=2)[CH2:16][CH2:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[CH:10][CH:9]=1.[OH-].[Na+].Cl>C1COCC1>[CH:34]([C:31]1[CH:30]=[CH:29][C:28]([C:25]2[CH:26]=[CH:27][C:22]([CH:15]([O:14][C:11]3[CH:10]=[CH:9][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:39])=[O:2])=[O:38])=[CH:13][CH:12]=3)[CH2:16][CH2:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[CH:23][C:24]=2[CH3:37])=[CH:33][CH:32]=1)([CH3:35])[CH3:36]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 673432783-{4-[1-(4'-Isopropyl-2-methyl-biphenyl-4-yl)-5-methyl-hexyloxy]-benzoylamino}-propionic acid methyl ester

생성물 1

HCID 597293793-{4-[1-(4'-Isopropyl-2-methyl-biphenyl-4-yl)-5-methyl-hexyloxy]-benzoylamino}-propionic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran
용매

실험 절차

3-{4-[1-(4′-Isopropyl-2-methyl-biphenyl-4-yl)-5-methyl-hexyloxy]-benzoylamino}-propionic acid methyl ester (50 mg) was taken into THF (1.0 mL) and treated with NaOH (1.0 mL, 5.0 N), then refluxed under nitrogen. The reaction mixture was neutralized with HCl (1.0 mL, 5.0 N), extracted with ethyl ether, dried over sodium sulfate. Concentration gave the title compound. MS (ES): 516.7 [M+H]+, the structure was also confirmed by proton NMR.

후처리

  1. temperaturerefluxed under nitrogen
  2. extractionextracted with ethyl ether
  3. dry with materialdried over sodium sulfate
  4. concentrationConcentration

출처 및 근거

ORD 기록
ord-457f48026f6644b88d4d21c62128016c
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07989457B2

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