Stannous Chloride → HCID 57770617, 화합물

HRID 1669884노트

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HRID 1669884 반응식
[CH3:1][O:2][CH2:3][CH:4]([NH:6][C:7]([C:9]1[CH:10]=[C:11]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)[CH:12]=[C:13]([NH2:15])[CH:14]=1)=[O:8])[CH3:5].[N:23]([O-])=O.[Na+].Cl[Sn]Cl>Cl.O>[CH3:1][O:2][CH2:3][CH:4]([NH:6][C:7]([C:9]1[CH:10]=[C:11]([C:16]2[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=2)[CH:12]=[C:13]([NH:15][NH2:23])[CH:14]=1)=[O:8])[CH3:5]

참가 물질

6

반응물 3

HCID 24479Stannous ChlorideHCID 23668193Sodium NitriteHCID 595997035-Amino-4'-methyl-biphenyl-3-carboxylic acid (2-methoxy-1-methyl-ethyl)-amide

생성물 1

HCID 57770617HCID 57770617, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매2회HCID 962Water용매

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온도
0 °C

실험 절차

5-Amino-4′-methyl-biphenyl-3-carboxylic acid (2-methoxy-1-methyl-ethyl)-amide (596 mg, 2 mmol) was dissolved in 6 mL of concentrated HCl and stirred for 15 minutes at 0° C. To the reaction mixture was added a solution of NaNO2 (138 mg, 2 mmol) in water (1.5 mL) dropwise at 0° C. The mixture was stirred for 30 minutes, and then a solution of SnCl2 (4.5 mmol, 189.6 mg) in 2 mL of concentrated HCl was added dropwise. A precipitate began to form immediately. After stirring for another 30 minutes, the resulting 5-hydrazino-4′-methyl-biphenyl-3-carboxylic acid (2-methoxy-1-methyl-ethyl)-amide was isolated as a hydrochloride salt by filtration and immediately used in the next step.

후처리

  1. stirringThe mixture was stirred for 30 minutes
  2. customto form immediately
  3. stirringAfter stirring for another 30 minutes

출처 및 근거

ORD 기록
ord-76c4582fdee543b68086e2a392871493
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989637B2

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